The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate repair in the context of oncogene-induced replication stress and elevated transcription. DNA replication is furthermore emerging as a surprisingly fragile and complex process requiring fork protection and restart, template-switching, R-loop resolution, gap-filling, and repair. Unresolved replication and repair intermediates signal apoptosis. The synthetic lethality and essentiality resulting from replication-repair stresses thus suggest repair inhibitors as tools to control pathway selection and damage outcomes and to design advanced therapeutics.
The meeting will focus on structural and mechanistic insights into dynamic protein, chromatin, DNA and RNA complexes acting in DNA replication and repair events relevant to cancer. Conference talks and discussions will center on developing an actionable mechanistic knowledge of DNA replication and repair stress responses suitable to guide advanced intervention strategies for cancer. The conference will emphasize an environment suitable for initiating productive collaborations. It will include vibrant informal and formal discussions together with informative talks and poster sessions.
To include late-breaking advances and innovating new investigators, one or more talks for every session will be selected from submitted abstracts. Meeting attendance is limited. Applicants seeking to present talks or posters are strongly encouraged to submit applications and abstracts early. All presenters are asked to focus on unpublished work, cutting-edge approaches and novel mechanistic insights that aid prediction of biological outcomes and plans to best apply basic research advances for cancer research and treatment.
Please note registration fees include fixed accommodation (11, 12, 13 and 14 Feb 2018), an all-inclusive food and beverage package and conference attendance.
2:00 pm - 12:00 pm
|Contact Person:||Conference Manager|
|Organizer State/Province: (Outside US)|
|Organizer Country||Data not provided|
|Structural makeup||Data not provided|
|Host Sponsor; Other Sponsors||Fusion Conferences|
|Event Site/Venue||FIESTA AMERICANA CONDESA CANCUN|
|Event sold out?||No|
|Multiple locations or dates?||No|
|Statistics available for most recent event held in:||NA|
|Average number in event attendance of:|
|Number in attendance of:|
|Is Registration contact information the same as Organizer Contact above?||Yes|
|Web Page ||https://go.evvnt.com/154651-1|
|Can one register for your CE on your web site?||NA|
|Can registration be made by snail (regular) mail?||Yes|
|Online housing reservations:|| |
|Do you have additional written or AV materials for sale?||No|
|If so, are they available for non-attendees as well as those attending?||NA|
|Is full tuition necessary to ensure registration?||No|
|Will there be shuttle service available?||NA|